Medications Altering Sex Hormone Balance And Risk Of Advanced Liver Disease In HCV-Infected Males

October 2011 in “ The American Journal of Gastroenterology ”

Ali Madeeh Hashmi, David J. Ramsey, Hashem B. El‐Serag, Shahriar Tavakoli Tabasi, Nathaniel Avila, Donna L. White, Jill Kuzniarek, Rhia Pascua

sex hormone balance anti-androgen methadone

TLDR Methadone may worsen liver fibrosis in males with HCV.

The study investigated the impact of medications altering sex hormone balance on the risk of advanced liver disease in 257 HCV-infected male veterans. It found that methadone use was significantly associated with a 4.5-fold increased risk of advanced liver fibrosis, while no significant association was observed with anti-androgen use, such as Finasteride. The study highlighted the need for further research in larger samples due to the low prevalence of methadone use in the population studied.

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