Marie Antoinette Syndrome Following COVID-19 Vaccination

    Maria Efenesia Baffa, Carlo Pipitò, Francesca Montefusco, Stefano Senatore, Luca Brandini, Emiliano Antiga, Roberto Maglie
    TLDR A woman experienced sudden hair graying and loss after a COVID-19 vaccine, which improved with treatment.
    A 39-year-old woman experienced sudden graying and diffuse hair loss, diagnosed as Marie Antoinette syndrome, following the Pfizer/BioNTech COVID-19 vaccine. The condition worsened after the second dose but improved significantly with oral prednisone and topical clobetasol treatment, showing almost complete hair regrowth and partial repigmentation after 6 weeks. This case, along with a review of 14 similar cases, suggests a potential link between mRNA COVID-19 vaccines and alopecia areata, particularly in females, with a need for further studies on long-term outcomes.
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