Male Pattern Alopecia Regrowth Following Topical Fluorouracil Therapy

September 1977 in “ JAMA ”

Robert L. Rietschel

male pattern alopecia topical fluorouracil fluorouracil actinic keratosis erythema edema triamcinolone hair regrowth male pattern baldness 5-FU steroid cream

TLDR A man regrew hair after using a 2% fluorouracil treatment on his scalp.

A 45-year-old man with a ten-year history of male pattern baldness began to regrow terminal hair after his scalp was treated with 2% fluorouracil for actinic keratosis. The treatment, which also included 0.5% triamcinolone acetonide cream, initially caused significant erythema and edema, leading to the discontinuation of fluorouracil. Upon follow-up several months later, hair regrowth was observed, suggesting a potential effect of fluorouracil on hair regrowth in male pattern baldness.

View this study on jamanetwork.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community Micro needling 25 days progress. I’ve been on fin and min for 6 months but micro needling has done SO much more to actually restore my hairline

in Progress Pictures 569 upvotes 8 months ago

A user shared a 25-day progress picture showing significant hairline restoration attributed to microneedling, in addition to using minoxidil and finasteride for 6 months. Other users discussed needle length, frequency, and whether the effects of microneedling are permanent.

community I 24F have gone from a full head of hair to ~30% of hair in 2 weeks

in Female 49 upvotes 2 years ago

A 24 year old female experiencing rapid, unexplained hair loss over the course of two weeks and looking for advice. Treatments suggested include Rogaine, finasteride, minoxidil, RU58841, and seeing a dermatologist.

community Why is it that low testosterone causes hair loss as well? How can I be balding?

in Chat 158 upvotes 7 months ago

The conversation discusses the confusion over low testosterone potentially causing hair loss, with users sharing personal experiences and knowledge about hair loss treatments like Finasteride. Some users suggest that hair follicle sensitivity to DHT, not testosterone levels, is the key factor in balding, and others discuss the side effects of hair loss medications.

community Taking Charge of Your Hair: The "Big 3 Stack" Explained for 2023

in Research/Science 129 upvotes 1 year ago

The "Big 3 Stack" for hair loss treatment, which includes Minoxidil for hair density improvement, Ketoconazole shampoo for enhancing hair volume and thickness, and Finasteride for blocking hair loss causing hormones. Microneedling can boost Minoxidil's effects.

community Treatment of male androgenetic alopecia with topical products containing Serenoa repens (Saw Palmetto) extract.

3 upvotes 9 years ago

The conversation discusses treating male pattern baldness with topical products containing Saw Palmetto extract. Specific treatments mentioned include Minoxidil, Finasteride, and RU58841.

community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 2 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

Similar Research

5 / 1000+ results

research Male Pattern Alopecia Regrowth Following Topical Fluorouracil Therapy

September 1977 in “JAMA”

A man regrew hair after using a specific cream for skin treatment.

research Is Androgenetic Alopecia a Photoaggravated Dermatosis?

62 citations, January 2003 in “Dermatology”

Sunlight worsens hair loss; protect scalp.

research Lessons Learned from the First Decade of Laser-Assisted Drug Delivery

17 citations, January 2021 in “Dermatology and Therapy”

Laser-assisted drug delivery has shown improved treatment outcomes for skin conditions and has potential to reduce side effects and treatment time.

research Atlas of Geriatric Dermatology

2 citations, January 2014 in “Springer eBooks”

The book details skin conditions in older adults, their link to mental health, cancer treatment importance, hair loss remedies, and managing autoimmune and itchy skin.

research Effect of Ultraviolet Radiation, Smoking, and Nutrition on Hair

19 citations, January 2015 in “Current problems in dermatology”

Ultraviolet rays damage hair, smoking may cause hair loss, and good nutrition is important for hair health, but genetics mainly decide hair thickness.