Sequelae of Long Covid, Known and Unknown: A Review of Updated Information

    March 2023 in “ BioScience Trends ”
    Tetsuya Asakawa, Qing Cai, Jiayin Shen, Ying Zhang, Yongshuang Li, Pei-Fen Chen, Wen Luo, Jiangguo Zhang, Jinfeng Zhou, Hui Zeng, Ruihui Weng, Feng Hu, Huiquan Feng, Jun Chen, Jie Huang, Xiaoyin Zhang, Yu Zhao, Liekui Fang, Rongqing Yang, Jia Huang, Fuxiang Wang, Yingxia Liu, Hongzhou Lu
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    TLDR The review indicates that understanding of long COVID symptoms is still limited and better research is needed for diagnosis and treatment.
    The document reviews the long-term symptoms, or "sequelae," associated with SARS-CoV-2 infection, also known as long COVID (LC). Despite previous documentation, understanding of LC-related sequelae remains limited due to issues such as inadequate follow-up, methodological flaws, and heterogeneity among studies. There is a lack of robust evidence regarding the diagnosis and treatment of certain LC sequelae, which hinders effective patient management. The authors of the review aim to provide updated information on LC-related sequelae, focusing on the involvement of main organ systems, and suggest paths for future research based on current knowledge and their clinical experience.
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