lncRNA H19 acts as a ceRNA to regulate the expression of CTGF by targeting miR-19b in polycystic ovary syndrome

The study investigated the role of lncRNA H19 in polycystic ovary syndrome (PCOS) by examining its interaction with miR-19b and CTGF in ovarian granulosa cells. It was found that H19 acted as a competing endogenous RNA (ceRNA) to bind miR-19b, thereby regulating CTGF expression. Overexpression of H19 led to decreased miR-19b and increased CTGF levels, promoting cell proliferation and reducing apoptosis. Conversely, silencing H19 had the opposite effects. The findings suggested that H19 might play a crucial role in PCOS pathogenesis by modulating CTGF through miR-19b, highlighting a potential target for therapeutic intervention.