Characterizing Lipid Changes and Use of Lipid-Lowering Medications in Patients With Alopecia Areata Treated With Baricitinib: Integrated Results From the BRAVE-AA1 and BRAVE-AA2 Clinical Trials

    November 2024 in “ SKIN The Journal of Cutaneous Medicine ”
    Ruth Ann Vleugals, Arash Mostaghimi, Rodney Sinclair, Bianca Maria Piraccini, Angelina Sontag, Najwa Somani, Karen Denning, Ayush Srivastava, Brett King
    TLDR Baricitinib slightly increased cholesterol levels in alopecia areata patients, but these changes were manageable.
    The study analyzed lipid changes and the use of lipid-lowering medications in patients with severe alopecia areata treated with baricitinib over 152 weeks, using data from the BRAVE-AA1 and BRAVE-AA2 trials. Among 1,303 patients, 43% had hypercholesterolemia at enrollment. Baricitinib treatment was associated with modest increases in total cholesterol, LDL-C, and HDL-C, consistent with JAK inhibitors' class effects. These changes stabilized within a year. Despite the prevalence of hypercholesterolemia, only 6.1% used lipid-lowering medications at baseline, with minimal changes post-baseline. No patients discontinued baricitinib due to lipid-related adverse events, indicating that lipid level increases were manageable.
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