Effect of Lentivirus-Mediated miR-182 Targeting FGF9 on Hallux Valgus

The study investigated the genetic factors involved in hallux valgus by examining the role of miR-182 and FGF9 in bone tissue. It was found that FGF9 expression was significantly higher in hallux valgus bone tissue compared to normal tissue, while miR-182 levels were lower. miR-182 was shown to negatively regulate FGF9 expression in osteoblasts, and FGF9 was found to enhance osteoblast proliferation. These findings suggested that miR-182 plays a crucial role in the development of hallux valgus by targeting FGF9, and it could be a potential therapeutic target for treating the condition.