Changes in Kidney Hemodynamics During Gender-Affirming Hormone Therapy in Transgender Individuals - Findings from the KNIGHT Pilot Study

    October 2024 in “ Journal of the Endocrine Society ”
    Sarah Annemieke van Eeghen, Chantal M. Wiepjes, Laura Pyle, Martin den Heijer, Petter Bjornstad, Daniël H. van Raalte, Natalie Nokoff
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    TLDR Feminizing hormone therapy increases kidney filtration rate.
    The KNIGHT pilot study investigated the effects of gender-affirming hormone therapy (GAHT) on kidney hemodynamics in transgender individuals. The study included 23 transgender individuals assigned male at birth receiving feminizing hormone therapy and 21 individuals assigned female at birth receiving masculinizing hormone therapy. Results showed that feminizing hormone therapy led to an increase in glomerular filtration rate (GFR) by 2.8 mL/min per 1.73m², likely due to afferent vasodilation, while masculinizing hormone therapy resulted in a slight, nonsignificant decrease in GFR. These findings suggest that sex hormones influence kidney hemodynamics, particularly during feminizing hormone therapy.
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