Changes in Kidney Hemodynamics During Gender-Affirming Hormone Therapy in Transgender Individuals - Findings from the KNIGHT Pilot Study

    October 2024 in “ Journal of the Endocrine Society ”
    Sarah Annemieke van Eeghen, Chantal M. Wiepjes, Laura Pyle, Martin den Heijer, Petter Bjornstad, Daniël H. van Raalte, Natalie Nokoff
    Image of study
    TLDR Feminizing hormone therapy increases kidney filtration rate.
    The KNIGHT pilot study investigated the effects of gender-affirming hormone therapy (GAHT) on kidney hemodynamics in transgender individuals. The study included 23 transgender individuals assigned male at birth receiving feminizing hormone therapy and 21 individuals assigned female at birth receiving masculinizing hormone therapy. Results showed that feminizing hormone therapy led to an increase in glomerular filtration rate (GFR) by 2.8 mL/min per 1.73m², likely due to afferent vasodilation, while masculinizing hormone therapy resulted in a slight, nonsignificant decrease in GFR. These findings suggest that sex hormones influence kidney hemodynamics, particularly during feminizing hormone therapy.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 108 results

      community 8 months on 5mg fin daily, 5% min twice daily, and hrt(mtf). Thought my hair was unrecoverable before but now I’m so happy.

      in Transgender  1896 upvotes 1 year ago
      A user named "LordGeek101" shared their positive experience with hair regrowth after using 5mg of finasteride daily, 5% minoxidil twice daily, and hormone replacement therapy (HRT) for 8 months. The user is transgender (MTF) and mentioned that the larger dose of finasteride was recommended by their doctor for better chances of hair revival.

      community Discussion on Finasteride and life.

      in Chat  162 upvotes 1 month ago
      Finasteride can aid hair regrowth but may cause side effects like depression and sexual dysfunction. Users discuss experiences with finasteride, minoxidil, and RU58841, highlighting varied responses and the importance of informed treatment choices.

      community Jordan Peterson got a sick hair transplant!

      in Transplants  1079 upvotes 9 months ago
      The conversation is about Jordan Peterson allegedly getting a hair transplant, with various users mocking his way of speaking and debating the ethics of him potentially hiding the procedure. Some users discuss the natural look of the transplant and the implications of getting one at an older age.

      community Well… I Did It. Estrogen Saved My Hairline

      in Transgender  718 upvotes 2 months ago
      OP transitioned and used Spironolactone, Estradiol Valerate, Minoxidil, and dermarolling, resulting in significant hair regrowth. They advise this method may not be suitable for cis men.

      community I think we all hop on estrogen. It's the only angle

      in Satire  83 upvotes 3 months ago
      The conversation humorously discusses hair loss treatments, including Minoxidil, finasteride, RU58841, and topical 17 alpha estradiol, with some users joking about transitioning to female to avoid baldness. The overall tone is satirical, emphasizing self-acceptance and the lengths people might consider for hair restoration.

    Similar Research

    5 / 1000+ results