Keratinocytes as Depository of Ammonium-Inducible Glutamine Synthetase: Age- and Anatomy-Dependent Distribution in Human and Rat Skin

    February 2009 in “ PLoS ONE
    Lusine Danielyan, Sebastian Zellmer, Stefan Sickinger … Gayane Hrachia Buniatian
    Studysummary This study found that the enzyme glutamine synthetase is distributed throughout the epidermis and its activity in keratinocytes is notably increased by ammonium ions, suggesting the skin serves as a reservoir for glutamine generation.
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    Research cited in this study 3

    1. The Targeted Overexpression of a Claudin Mutant in the Epidermis of Transgenic Mice Elicits Striking Epidermal and Hair Follicle Abnormalities Molecular Biotechnology · 2007
    2. Controlling the Stem Cell Niche: Right Time, Right Place, Right Strength BioEssays · 2005
    3. Keratin 19 as a Biochemical Marker of Skin Stem Cells In Vivo and In Vitro: Localization and Variation with Age and Culture Stage Journal of Cell Science · 1996