Keratinocytes as Depository of Ammonium-Inducible Glutamine Synthetase: Age- and Anatomy-Dependent Distribution in Human and Rat Skin

February 2009 in “ PLoS ONE ”

Lusine Danielyan, Sebastian Zellmer, Stefan Sickinger, Genrich V. Tolstonog, Jürgen Salvetter, Ali Lourhmati, Dieter Reißig, Cristoph H. Gleiter, Rolf Gebhardt, Gayane Hrachia Buniatian

keratinocytes glutamine synthetase nitrogen metabolism skin physiology skin pathology

TLDR Keratinocytes help manage skin nitrogen metabolism, varying by age and skin area.

The study investigated the role of keratinocytes as a storage site for ammonium-inducible glutamine synthetase in human and rat skin, focusing on how its distribution varied with age and anatomical location. The research found that the presence of glutamine synthetase in keratinocytes was influenced by both the age of the individual and the specific area of the skin. This suggested that keratinocytes played a significant role in managing nitrogen metabolism in the skin, with potential implications for understanding skin physiology and pathology.

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Keratinocytes as Depository of Ammonium-Inducible Glutamine Synthetase: Age- and Anatomy-Dependent Distribution in Human and Rat Skin

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research Keratin 19 as a Biochemical Marker of Skin Stem Cells In Vivo and In Vitro: Localization and Variation with Age and Culture Stage

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