Keratinocytes as Depository of Ammonium-Inducible Glutamine Synthetase: Age- and Anatomy-Dependent Distribution in Human and Rat Skin

    February 2009 in “ PLoS ONE
    Lusine Danielyan, Sebastian Zellmer, Stefan Sickinger, Genrich V. Tolstonog, Jürgen Salvetter, Ali Lourhmati, Dieter Reißig, Cristoph H. Gleiter, Rolf Gebhardt, Gayane Hrachia Buniatian
    Studysummary This study found that the enzyme glutamine synthetase is distributed throughout the epidermis and its activity in keratinocytes is notably increased by ammonium ions, suggesting the skin serves as a reservoir for glutamine generation.
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