Juvenile Diabetes Mellitus With Exocrine Pancreatic Insufficiency in a Thai Bangkaew Dog: A Case Report

An 8-month-old Thai Bangkaew dog exhibited symptoms of diabetes mellitus, including polyuria, polydipsia, polyphagia, and weight loss, which improved with intermediate-insulin treatment. Two months later, the dog developed symptoms of exocrine pancreatic insufficiency, such as voluminous diarrhea, greasy stools, dry coat hair, and generalized alopecia. Diagnostic tests indicated low levels of canine-trypsin-like immunoreactivity and cobalamin, suggesting exocrine pancreas loss of function, while ultrasonography pointed to immune-mediated pancreatic fibrosis. Successful treatment involved low-dose insulin, pancreatic enzymes, and methylcobalamin, leading to weight gain and improved exercise tolerance. This case highlighted the concurrent occurrence of juvenile diabetes mellitus and exocrine pancreatic insufficiency in a Thai Bangkaew dog, suggesting potential hereditary and economic implications for the breed.