Treatment of Tinea Capitis Caused by Microsporum Ferrugineum with Itraconazole

    November 2005 in “ PubMed ”
    Wanee Wisuthsarewong, Angkana Chaiprasert
    TLDR Itraconazole effectively treats scalp fungus, with continuous use more effective than pulse therapy.
    In a clinical trial conducted 18 years ago, 81 patients (49 boys and 32 girls) suffering from tinea capitis caused by Microsporum ferrugineum were treated with itraconazole. The patients were divided into two groups: one received continuous itraconazole treatment and the other received pulse therapy (one week on, three weeks off). Both groups also used 2% ketoconazole shampoo daily. The study found that the overall clinical severity score decreased with each visit (p < 0.001), with no significant difference between the two groups. However, the cumulative cure rate at week 16 was higher in the continuous treatment group (54.3% or 19 out of 35 patients) compared to the pulse therapy group (37.0% or 17 out of 46 patients). The study concluded that continuous itraconazole treatment was more effective, especially after week 8, and suggested that a higher dosage or longer treatment duration may be required to increase the cure rate. No significant adverse effects were reported.
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