Ion Sequential Therapy Aligned With Pathological Changes Enhances Cardiac Function After Myocardial Infarction

This study explores the use of Zn-Cu ion sequential therapy to enhance cardiac function after myocardial infarction by addressing trace element imbalances. By observing temporal and spatial shifts in zinc and copper ions, researchers developed a therapy that aligns with the body's phased requirements for these ions. In a rat model, this therapy significantly improved cardiac function and cardiomyocyte metabolic activity by regulating the Period circadian protein homolog 2 (Per2), linked to circadian rhythm. The therapy uses a perfusable multifunctional epicardial device to maintain a stable ion microenvironment, optimizing cardiomyocyte repair and regeneration. This approach offers a new therapeutic concept for addressing ion imbalances in various diseases.