Investigation of the efficacy of fish scale collagen peptide on wound healing through various administration routes

This study investigated the efficacy of fish scale collagen peptide (FSCP) in promoting wound healing in a mouse model with full-thickness skin injuries, using gavage and topical administration methods. FSCP and its fractions significantly accelerated wound healing by shortening scab-shedding time, increasing granulation tissue, hair follicle, and capillary production, and enhancing collagen remodeling. The most effective FSCP fractions were those smaller than 1 kDa, achieving wound healing rates of 99.66% and 99.63% for gavage and topical administration, respectively. The study also identified bioactive peptides, such as APDPFR, GTPIQF, and TPIQF, with potential therapeutic benefits, highlighting FSCP's value in clinical wound treatment.