Intravital imaging of hair-cell development and regeneration in the zebrafish
January 2013
in “
Frontiers in Neuroanatomy
”
TLDR Zebrafish can help study and develop treatments for hearing loss.
The document described a method for studying sensory hair-cell development and regeneration in zebrafish using high-resolution intravital imaging techniques like laser-scanning confocal microscopy and selective plane illumination microscopy. This approach allowed for continuous videomicroscopy for up to 68 hours, enabling direct observation of cellular behavior in a natural context. The study highlighted the advantage of using zebrafish, as hair-cell regeneration occurs throughout their life, providing a natural model for research. The method aimed to facilitate pharmacogenetic assays to identify or validate drugs that could protect or repair auditory function, potentially informing future clinical strategies for humans.
