Insulin-like growth factor-1: roles in androgenetic alopecia

    March 2014 in “ Experimental Dermatology
    Ratchathorn Panchaprateep, Pravit Asawanonda
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    TLDR IGF-1 affects hair loss and could be a potential treatment.
    Insulin-like growth factor-1 (IGF-1) plays a role in androgenetic alopecia (AGA), a common form of hair loss. DP cells from balding scalp follicles secrete significantly less IGF-1 than those from non-balding scalps, and IGF-respective-binding proteins (IGFBP-2, IGFBP-4) are downregulated in balding DP group. The downregulation of IGF-1 is one of the important mechanisms contributing to male pattern baldness. IGF-1 might be considered as a new therapeutic option for hair loss.
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