In Vivo Investigation in Pigs of Intestinal Absorption, Hepatobiliary Disposition, and Metabolism of the 5α-Reductase Inhibitor Finasteride and the Effects of Coadministered Ketoconazole
May 2011
in “Drug Metabolism and Disposition”
TLDR Ketoconazole increases finasteride's effectiveness and lifespan in the body.
This study investigated the pharmacokinetics and metabolism of finasteride, a 5α-reductase inhibitor used to treat benign prostatic hyperplasia and male pattern baldness, in pigs. The study found that ketoconazole increased the bioavailability of finasteride and the terminal half-life. The liver extraction ratio was time-dependent and varied with the two routes of administration. After intrajejunal administration, the liver extraction ratio was significantly reduced by ketoconazole treatment. The study provides valuable insights into the pharmacokinetics of finasteride and its interactions with other drugs.
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Cited in this study
research Saturable Binding of Finasteride to Steroid 5α-reductase as Determinant of Nonlinear Pharmacokinetics
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research Identification of Finasteride Metabolites in Human Bile and Urine by High-Performance Liquid Chromatography/Tandem Mass Spectrometry
Finasteride breakdown products found in bile and urine, helps understand drug safety and effectiveness.
research The effect of St. John’s wort on the pharmacokinetics, metabolism and biliary excretion of finasteride and its metabolites in healthy men
St. John's wort increases finasteride metabolism, reducing its effectiveness; use caution when combining them.
research Clinical Pharmacokinetics and Pharmacodynamics of Finasteride
Finasteride helps regrow hair and shrink prostate by reducing DHT, with some sexual side effects.
research Finasteride, A Steroid 5α-Reductase Inhibitor, Does Not Affect the Oxidative Metabolism of Antipyrine
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research Finasteride: the first 5 alpha-reductase inhibitor.
Related
research The effect of St. John’s wort on the pharmacokinetics, metabolism and biliary excretion of finasteride and its metabolites in healthy men
St. John's wort increases finasteride metabolism, reducing its effectiveness; use caution when combining them.