In-Vitro Anticancer Activity of Chemical Constituents from Etlingera alba Poulsen against Triple Negative Breast Cancer and in silico Approaches towards Matrix metalloproteinase-1 Inhibition

    May 2022 in “ Indonesian Journal of Science and Technology ”
    Wahyuni Wahyuni, Ajeng Diantini, Mohammad Ghozali, Anas Subarnas, Euis Julaeha, Riezki Amalia, Adryan Fristiohady, Andini Sundowo, Sofa Fajriah, Yuni Elsa Hadisaputri, Raden Maya Febrianti, Fauzia Azzahra, Agung Wibawa Mahatva Yodha, Idin Sahidin
    TLDR Compounds from Etlingera alba may help treat Triple Negative Breast Cancer.
    The study investigated the anticancer properties of chemical constituents from Etlingera alba rhizome extract against Triple Negative Breast Cancer. The compounds 1,7-diphenyl-6-heptene-3-one, sitostenone, sinapyl alcohol diacetate, and sinapyl alcohol acetate showed cytotoxic activity with IC50 values of 134.59, 170, 128.11, and 161.96 μg/mL, respectively. Sitostenone demonstrated the most significant anti-migration activity with a migration rate of 3.32% at 200 μg/mL. Additionally, these compounds effectively stabilized the Matrix metalloproteinase 1 complex, with sitostenone having the lowest free bond energy of -11.81 kcal/mol. The findings suggested that isolates from EA rhizomes could be developed as anti-metastatic agents for treating Triple-Negative Breast Cancer.
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