Imported Cutaneous Leishmaniasis in Japan

    November 1990 in “ International Journal of Dermatology ”
    Juichiro Nakayama, Tadahiko Matsumoto, Masakazu Asahi, Harukuni Urabe
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    TLDR Albendazole can cause hair loss, and piroxicam can cause fixed drug eruption.
    In 1990, a 59-year-old woman experienced sudden diffuse hair loss, diagnosed as telogen effluvium, due to albendazole therapy for hydatid disease of the liver. Her hair loss stopped after reducing the albendazole dosage from 400 mg to 200 mg daily. This case highlighted the need for awareness of potential hair loss side effects from albendazole. Additionally, the document reported a case of fixed drug eruption (FDE) in a patient who had mucosal and cutaneous lesions after taking 20 mg piroxicam. Patch tests were positive only on previous FDE lesions, and an oral provocation test confirmed piroxicam as the causative agent. The document suggests that identifying the responsible drug for FDE can be difficult, but the patient's specific reaction to piroxicam was crucial for diagnosis.
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