Immunological Aspects of Psychodermatology

The document discussed the immunological and psychodermatological aspects of the skin, highlighting its complex structure and functions. The skin, being the largest organ, played a crucial role in protection, nutrient storage, thermoregulation, and communication through its extensive innervation and glandular functions. It shared a common embryonic origin with the nervous system, which contributed to its neuroendocrine capabilities. The skin's immune functions included both innate and acquired immunity, with mechanisms to recognize pathogens and maintain tolerance to nonpathogenic flora. It was involved in allergic and autoimmune reactions in certain individuals. Additionally, the skin had a local hypothalamic-hypophyseal-adrenal axis, producing hormones like CRF, ACTH, and cortisol, which, along with its innervation, allowed it to participate in psycho-endocrine and psycho-immunological responses, reflecting emotional states and stress reactions.