Immunohistochemical Localization of TGF-β in Alopecia Areata

July 1997 in “ JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology ”

Uwe Wollina, D. Lange, Keiko Funa, Ralf Paus

Transforming Growth Factor-beta TGF-β alopecia areata hair follicles cytokine immune-mediated attack hair loss pathogenesis TGF-beta hair follicles cytokine immune attack hair loss

TLDR TGF-β is found in hair follicles and may cause hair loss in alopecia areata.

The study investigated the presence and distribution of Transforming Growth Factor-beta (TGF-β) in patients with alopecia areata using immunohistochemical techniques. The researchers found that TGF-β was localized in the hair follicles of affected individuals, suggesting a potential role of this cytokine in the pathogenesis of alopecia areata. The findings indicated that TGF-β might contribute to the immune-mediated attack on hair follicles, leading to hair loss. This study provided insights into the molecular mechanisms underlying alopecia areata and highlighted TGF-β as a possible target for therapeutic intervention.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 29 results

community Taurine supplements work for hair growth?

in Product 8 upvotes 6 months ago

The conversation discusses taurine supplements for hair growth, highlighting their potential to reduce DHT and improve hair health. A user comments that people often try alternatives to finasteride.

community Possible topical option for preventing BDNF-related hair loss

in Research/Science 7 upvotes 1 year ago

The conversation discusses hair loss linked to BDNF-increasing nootropics like Semax and Lions Mane. Suggested topical treatments include capsaicin, beta-glucan, and ginseng to counteract TGF-B activation.

community The theory that explains everything. Please help me make this big!

in Research/Science 2448 upvotes 3 years ago

The post and conversation are about the role of the enzyme 3alpha-hydroxysteroid reductase in hair loss and the potential of compounds like procyanidin B2 and sulforaphane to boost its activity for hair regrowth. Further research is needed to develop effective treatments based on this theory.

community SAFFLOWER OIL good alternative for Minoxidil?

in Treatment 1 upvotes 4 years ago

Safflower oil is suggested as an alternative to minoxidil for hair growth, with benefits including scalp conditioning and hair strength enhancement. Studies indicate it may also reverse scalp dermatitis, alopecia, and prevent premature grayness.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 668 upvotes 1 month ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community ladies and gentlmen, vitamin E is your hair follicles second best friend

in Treatment 51 upvotes 2 years ago

Vitamin E is suggested as beneficial for hair follicles. Some users question the dosage and effectiveness, while others share positive experiences with vitamins.

Related Research

1 / 1 results

research Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child

April 2019 in “International journal of research in dermatology”

A child with rough nails also had hair loss and allergies.