Immunohistochemical Localization of TGF-β in Alopecia Areata

July 1997 in “ JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology ”

Uwe Wollina, D. Lange, Keiko Funa, Ralf Paus

Transforming Growth Factor-beta TGF-β alopecia areata hair follicles cytokine immune-mediated attack hair loss pathogenesis TGF-beta hair follicles cytokine immune attack hair loss

TLDR TGF-β is found in hair follicles and may cause hair loss in alopecia areata.

The study investigated the presence and distribution of Transforming Growth Factor-beta (TGF-β) in patients with alopecia areata using immunohistochemical techniques. The researchers found that TGF-β was localized in the hair follicles of affected individuals, suggesting a potential role of this cytokine in the pathogenesis of alopecia areata. The findings indicated that TGF-β might contribute to the immune-mediated attack on hair follicles, leading to hair loss. This study provided insights into the molecular mechanisms underlying alopecia areata and highlighted TGF-β as a possible target for therapeutic intervention.

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