Identification of Telogen Markers Underscores that Telogen Is Far from a Quiescent Hair Cycle Phase

The study identified 425 differentially expressed genes in telogen phase hair follicles, revealing that telogen is a highly dynamic phase rather than a quiescent one. These genes fell into three major clusters, with significant functions in proteolysis, rhythmic processes, cholesterol metabolism, and actinomyosin structure organization. Notably, genes like adipocyte enhancer binding protein 1 (Aebp1) and Keratin 24 showed significant upregulation in telogen, suggesting new regulatory roles. The findings challenged the traditional view of telogen as a resting phase, highlighting its active biological processes and regulatory significance in hair follicle cycling.