I‐Ascorbic acid 2‐phosphate represses the dihydrotestosterone‐induced dickkopf‐1 expression in human balding dermal papilla cells
November 2010
in “Experimental Dermatology”
TLDR Vitamin C derivative reduces hair loss-related protein in cells.
The study explored the effects of L-ascorbic acid 2-phosphate (Asc 2-P) on the production of dickkopf-1 (DKK-1), which is associated with hair loss, in human balding dermal papilla cells (DPCs) when exposed to dihydrotestosterone (DHT). The results showed that Asc 2-P reduced the levels of DKK-1 mRNA and protein induced by DHT, as determined by RT-PCR and ELISA. Furthermore, Asc 2-P inhibited the activation of a DKK-1 promoter-driven luciferase reporter gene by DHT. These outcomes indicate that Asc 2-P or its derivatives could potentially be useful in treating and preventing hair loss caused by androgens. The study was conducted on cells, not live subjects, and does not specify the number of individuals from whom the cells were derived.
View this study on onlinelibrary.wiley.com →
Cited in this study
research l-Ascorbic acid 2-phosphate promotes elongation of hair shafts via the secretion of insulin-like growth factor-1 from dermal papilla cells through phosphatidylinositol 3-kinase
Vitamin C derivative helps hair grow longer by making cells produce a growth factor through a specific cellular pathway.
research Transcriptional activation of CCN1 and CCN2, targets of canonical Wnt signal, by ascorbic acid 2-phosphate in human dermal papilla cells
Vitamin C derivative may promote hair growth by activating specific genes.
research Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes
A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.
research L ‐Carnitine–L ‐tartrate promotes human hair growth in vitro
L-Carnitine-L-tartrate may help hair grow and prevent hair loss.
research Induction of versican by ascorbic acid 2-phosphate in dermal papilla cells
Vitamin C derivative increases versican in cells, potentially aiding hair growth.
research The hair growth promoting effect of ascorbic acid 2-phosphate, a long-acting Vitamin C derivative
A long-acting Vitamin C derivative helps hair grow by stimulating cells and increasing growth factors.
research Transfollicular drug delivery—Is it a reality?
Hair follicles may soon be used more for targeted and systemic drug delivery.
research Androgen‐inducible TGF‐β1 from balding dermal papilla cells inhibits epithelial cell growth: a clue to understanding paradoxical effects of androgen on human hair growth
Androgens may cause hair loss by increasing TGF-beta1 from scalp cells, which inhibits hair cell growth.
research WNT Signaling in the Control of Hair Growth and Structure
The research shows that a gene called Wnt3 affects hair growth and structure, causing short hair and balding when overactive.