Hyperprolactinemia in Patients with High TSH Levels with Both Clinical and Subclinical Hypothyroidism

    April 2022 in “ PANACEA JOURNAL OF MEDICAL SCIENCES ”
    Jyotindra Kumar Sahu, M Ravikant, A. K. Thakur
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    TLDR People with both obvious and not-so-obvious underactive thyroid issues often have higher levels of the hormone prolactin.
    The study "Hyperprolactinemia in patients with high TSH levels with both clinical and subclinical hypothyroidism" involved 138 patients with thyroid-related issues. The research found that serum prolactin levels were significantly increased in both subclinical (28.7 ± 6.4 ng/mL) and clinical hypothyroidism (15.02 ± 4.2ng/mL) compared to controls. Hyperprolactinemia was observed in 22.9% of patients with subclinical hypothyroidism and 8.3% of patients with clinical hypothyroidism. The study concluded that prolactin regulation is altered in patients with both clinical and subclinical hypothyroidism, suggesting that thyroid function tests should be conducted in patients with hyperprolactinemia before performing further tests.
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      in Research/Science  10 upvotes 1 year ago
      The potential of lowering prolactin levels to regrow hair, with a reference to Bayer's drug HMI 115 which has been indicated as having this effect. Treatments mentioned include Minoxidil and Finasteride, as well as RU58841.

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      in Research/Science  23 upvotes 7 months ago
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      in Technology  104 upvotes 1 year ago
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      community HLT Megathread on HMI-115 (key takeaways in comments)

      in Research/Science  39 upvotes 1 year ago
      HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

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      in Update  35 upvotes 5 years ago
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