Carrier-Free Injectable Hydrogel Self-Assembled Using Natural Thymol and Glycyrrhizin for MRSA-Infected Wound Healing in Rats

April 2024 in “ Chemical engineering journal ”

Zhengwei Cui, Xiaolu Zhang, Liping Zhang, Wei Dong, Yanjun Wei, Zongtao Liu, Xianggen Wu

thymol glycyrrhizin hydrogel MRSA wound healing antibacterial glycymicelles physical crosslinking THY DG methicillin-resistant Staphylococcus aureus

TLDR The new hydrogel made from thymol and glycyrrhizin helps heal MRSA-infected wounds in rats effectively.

The study developed a novel, carrier-free, injectable hydrogel (THY@glycygel) using natural thymol (THY) and dipotassium glycyrrhizinate (DG) through eco-friendly physical crosslinking without chemical agents. This hydrogel can transform back into THY-loaded glycymicelles (THY@glycymicelles) by adjusting the pH, maintaining its properties. THY@glycygel demonstrated excellent antibacterial performance, particularly against methicillin-resistant Staphylococcus aureus (MRSA), and promoted wound healing in rats, suggesting its potential as an effective alternative to antibiotics for treating bacterial infections in wounds.

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Carrier-Free Injectable Hydrogel Self-Assembled Using Natural Thymol and Glycyrrhizin for MRSA-Infected Wound Healing in Rats

Research cited in this study

research Hyaluronate and Gelatin-Based Hydrogels Encapsulating Doxycycline as a Wound Dressing for Burn Injury Therapy

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