Carrier-Free Injectable Hydrogel Self-Assembled Using Natural Thymol and Glycyrrhizin for MRSA-Infected Wound Healing in Rats

April 2024 in “ Chemical engineering journal ”

Zhengwei Cui, Xiaolu Zhang, Liping Zhang, Wei Dong, Yanjun Wei, Zongtao Liu, Xianggen Wu

thymol glycyrrhizin hydrogel MRSA wound healing antibacterial glycymicelles physical crosslinking THY DG methicillin-resistant Staphylococcus aureus

TLDR The new hydrogel made from thymol and glycyrrhizin helps heal MRSA-infected wounds in rats effectively.

The study developed a novel, carrier-free, injectable hydrogel (THY@glycygel) using natural thymol (THY) and dipotassium glycyrrhizinate (DG) through eco-friendly physical crosslinking without chemical agents. This hydrogel can transform back into THY-loaded glycymicelles (THY@glycymicelles) by adjusting the pH, maintaining its properties. THY@glycygel demonstrated excellent antibacterial performance, particularly against methicillin-resistant Staphylococcus aureus (MRSA), and promoted wound healing in rats, suggesting its potential as an effective alternative to antibiotics for treating bacterial infections in wounds.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

1 / 1 results

research Hyaluronate and Gelatin-Based Hydrogels Encapsulating Doxycycline as a Wound Dressing for Burn Injury Therapy

10 citations, April 2023 in “Acta biomaterialia”

New hydrogel dressing with antibiotic speeds up burn healing and skin regeneration.

Similar Research

5 / 94 results

Flavonoids and Saponins: What Have We Got or Missed?

Carrier-Free Injectable Hydrogel Self-Assembled Using Natural Thymol and Glycyrrhizin for MRSA-Infected Wound Healing in Rats

Research cited in this study

research Hyaluronate and Gelatin-Based Hydrogels Encapsulating Doxycycline as a Wound Dressing for Burn Injury Therapy

Related Community Posts Join

community Due to the virus, I can't get rubbing alcohol to sterilize my dermaroller after use. Would Listerine work as an alternative?

community Been doing daily 3% topical peppermint oil for 6+ months (never used minoxidil). Have had growth that seems as good as minoxidil. Might strenghten the idea that peppermint is a good low-cost treatment, that potentially works by another route than minoxidil.

Similar Research

research Flavonoids and Saponins: What Have We Got or Missed?

research From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

research Incredible Combination of Lifestyle Modification and Herbal Remedies for Polycystic Ovarian Syndrome Management

research Essential Oils and Melatonin as Functional Ingredients in Dogs

research Traditional Knowledge Digital Library: The Challenges Ahead