Hormonal Profile and Androgen Receptor Study in Prepubertal Girls with Hypertrichosis

April 2014 in “ International Journal of Pediatric Endocrinology ”

María Isabel Hernández, Andrea Castro, Ketty Bacallao, Alejandra Ávila, Aníbal Espinoza, León Trejo, Germán Íñiguez, Ethel Codner, Fernando Cassorla

hypertrichosis androgen receptor SHBG androgen-sensitive haplotypes gonadotropins sex steroids androgen receptor methylation

Studysummary This study concluded that prepubertal girls with hypertrichosis have androgen receptors with enhanced sensitivity, which may contribute to their increased body hair growth.

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Research cited in this study

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research Shorter CAG Repeats in the Androgen Receptor Gene May Enhance Hyperandrogenicity in Polycystic Ovary Syndrome

37 citations , January 2008 in “Gynecological Endocrinology”

This study found that in women with polycystic ovary syndrome, shorter CAG repeat lengths in the androgen receptor gene were associated with lower dihydrotestosterone and androstenedione levels, but a higher prevalence of acne and hirsutism.

research Decreased Androgen Receptor Gene Methylation in Premature Pubarche: A Novel Pathogenetic Mechanism?

53 citations , January 2006 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

In this study, reduced androgen receptor gene methylation and shorter CAG repeats in children with premature pubarche may lead to increased hair follicle sensitivity to steroid hormones, potentially causing early pubic hair development.

research Causes and Management of Hypertrichosis

61 citations , January 2002 in “American Journal of Clinical Dermatology”

research Drug-Induced Hair Loss and Hair Growth

147 citations , April 1994 in “Drug Safety”

Some drugs can cause hair loss or increase hair growth, but these effects are usually reversible when the drug is stopped.

research Bioactive and Peripheral Androgens in Prepubertal Simple Hypertrichosis

11 citations , September 1990 in “Clinical Endocrinology”

This study found that girls with prepubertal simple hypertrichosis had significantly higher plasma levels of dihydrotestosterone compared to controls, which does not align with other androgen markers and warrants further investigation.

research Topical Minoxidil for Hair Regrowth

80 citations , September 1984 in “Journal of The American Academy of Dermatology”

In this study, 5% topical minoxidil was observed to promote hair regrowth in some patients with androgenic alopecia, while no regrowth was noted in patients with alopecia areata.