Histopathologic Prognostic Factors for Alopecia Areata Treated by Intralesional Corticosteroid

April 2016 in “ Journal of The American Academy of Dermatology ”

alopecia areata intralesional corticosteroid vellus hairs follicular streamers catagen hairs telogen hairs terminal:vellus hair ratio lymphocyte infiltration polytrichia AA steroid injections

TLDR Certain scalp tissue features can predict how well alopecia areata responds to steroid injections.

The study from 2016 investigated histopathologic factors that could predict the response to intralesional corticosteroid treatment in patients with alopecia areata (AA). Out of 113 patients clinically diagnosed with AA, 97 were confirmed by histopathologic study, and 73 continued treatment for 6 months. The results showed that the presence of vellus hairs, follicular streamers, catagen hairs, telogen hairs, and a higher terminal:vellus hair ratio at the 3-month period were significantly associated with a better response to treatment. Conversely, higher levels of lymphocyte infiltration around muscle and polytrichia at the 6-month period were associated with a poor response. The study concluded that certain histopathologic features can serve as prognostic factors for the effectiveness of intralesional corticosteroid treatment in AA.

View this study on jaad.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community 2020 Hair and Scalp Treatments: A Clinical Guide (in Depth 350 Page Guide)

in Treatment 64 upvotes 4 years ago

Treatments for hair loss, including topical immunotherapy, regenerative treatments, laser and light-based therapies, oral supplements, intralesional steroids, and new drugs like finasteride and minoxidil.

community Alopecia Areata Question

in Treatment 2 upvotes 3 years ago

A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.

community mbp alopecia areata or vitamin deficiency

in Chat 5 months ago

A 19-year-old male has been using topical finasteride and minoxidil for 8 months with no progress and is considering seeking a second opinion due to potential misdiagnosis. The discussion revolves around whether the hair loss is due to male pattern baldness, alopecia areata, or a vitamin deficiency.

community Olumiant alternative for Alopecia Areata?

in Treatment 1 upvotes 1 year ago

A user with alopecia areata is considering treatment options like injections or Olumiant but is concerned about cost and whether delaying treatment will lead to permanent hair loss. They are seeking alternative treatments that are more affordable for a college student.

community Covid (likely) induced alopecia areata - now 2nd round of Covid, what can I expect?

in Treatment 1 upvotes 1 year ago

After experiencing hair loss due to alopecia areata following COVID-19 vaccination and infection, the individual saw improvement with steroid treatments and Olumiant. They paused Olumiant during a second COVID-19 infection and expressed concern about potential hair loss flare-ups.

community Onion Juice - An effective topical treatment for Alopecia Areata 🧬

in Treatment 1 year ago

Onion juice, when applied topically, is an effective treatment for Alopecia Areata, showing significant hair regrowth in both males and females. The study suggests it could be interesting to test its effectiveness on Androgenic Alopecia.

Related Research

1 / 1 results

research Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child

April 2019 in “International journal of research in dermatology”

A child with rough nails also had hair loss and allergies.