Hirsutism in Females: A Clinical Study of Its Etiology, Course, and Treatment

    June 1945 in “ Annals of Internal Medicine ”
    Grosvenor W. Bissell, Robert H. Williams
    TLDR Hirsutism in females is complex, often linked to tumors, and requires more research for better treatment.
    The study on hirsutism in females examines the causes, progression, and treatment of the condition, which is frequently associated with adrenal, pituitary, or ovarian tumors. It emphasizes the significant physiological and psychological effects on women, including virilization. Despite advancements in endocrine physiology, there is still much to learn. Improved chemical and biological techniques have enhanced the ability to identify the origins of the disorder. The research highlights the complexity of hirsutism and the necessity for ongoing research to improve understanding and treatment.
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      community DHT levels after 4 weeks of Fina and 8 weeks of Fina + 4 weeks of Duta

      in Update  38 upvotes 6 years ago
      The user reported early stage diffuse hair thinning and increased DHT levels after 4 weeks on Finasteride and 8 weeks on Finasteride plus 4 weeks on Dutasteride, despite the medications being authentic and stored properly. They are considering increasing their Dutasteride dosage due to the lack of side effects and are unsure if the treatment is helping their hair.

      community How does hair loss and recovery work?

      in Chat  12 upvotes 1 year ago
      Hair loss varies due to genetic sensitivity to DHT and other factors. Treatments discussed include finasteride, minoxidil, RU58841, and microneedling.

      community Bile Acid-Mediated DHT Dysregulation Hypothesis

      in Research/Science  13 upvotes 1 year ago
      Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.

      community AA and Hirsutism but T levels are normal

      in Female  6 upvotes 4 years ago
      27-year-old female experiences aggressive hair thinning and hirsutism despite normal testosterone levels. Spironolactone and 2% minoxidil were ineffective; high DHEA sulfate levels may be the cause.

      community Finasteride 5mg & Spironolactone 100mg

      in Female  2 upvotes 1 year ago
      A 20-year-old female is using finasteride 5mg and spironolactone 100mg for severe hirsutism and is experiencing minor side effects like water weight loss and irregular periods. She is concerned about potential future side effects and hair regrowth on her scalp.

      community No, Finasteride as a treatment for MPB was not an "accident"

      in Research/Science  108 upvotes 4 years ago
      Finasteride was intentionally developed to treat BPH and later approved for male pattern baldness (MPB) due to its 5AR inhibition effects. The delay in MPB approval was due to concerns about off-label use for female hirsutism and the prioritization of treating a more debilitating condition.

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