Hepatotoxicity Complicating Flutamide Treatment of Hirsutism

December 1993 in “ Annals of internal medicine ”

Clarissa Wallace

flutamide hirsutism antiandrogen hepatotoxicity liver toxicity

TLDR Flutamide, a medication used for excessive hair growth, can cause severe liver damage in women.

The document discussed the hepatotoxicity associated with flutamide treatment for hirsutism. It highlighted that flutamide, a pure antiandrogen, could lead to liver toxicity, which had been previously observed in prostate cancer patients. The study underscored the importance of monitoring liver function in patients undergoing flutamide treatment due to the risk of both fatal and nonfatal hepatotoxicity.

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4 / 4 results

research [Finasteride and flutamide in the treatment of hirsutism].

1 citations , October 1997 in “PubMed”

Finasteride and flutamide can effectively treat hirsutism, with abdominal hairs showing the most sensitivity to the treatment.

research Clinical efficacy and safety of low‐dose flutamide alone and combined with an oral contraceptive for the treatment of idiopathic hirsutism

36 citations , November 1995 in “Clinical endocrinology”

Low-dose flutamide helps reduce excessive hair growth and is even more effective with birth control, without bad effects on blood fats.

research Comparison of flutamide and spironolactone in the treatment of hirsutism: a randomized controlled trial

165 citations , February 1994 in “Fertility and Sterility”

Flutamide is more effective and has fewer side effects than spironolactone for treating hirsutism.

research Treatment of hirsutism with the pure antiandrogen flutamide

130 citations , September 1990 in “Journal of the American Academy of Dermatology”

Flutamide effectively reduced excessive hair growth and improved related symptoms in hirsutism patients without significant side effects.