Stimulation of Hair Regrowth Using Low-Level Laser Treatment in a Rat Model of Alopecia

January 2013

Meda Sandra Orăsan, Pompei Bolfă, Andrei Coneac, R. Moldovan, Carmen Mihaela Mihu

low-level laser therapy LLLT Neoptide HairMax Professional 12 Laser D68-1 Marp hair regrowth alopecia anagen induction follicle count skin thickness laser therapy HairMax

TLDR Low-level laser therapy combined with Neoptide improved hair regrowth better than either treatment alone in rats.

The study investigated the effects of low-level laser therapy (LLLT) on hair regrowth in a rat model of alopecia, using different LLLT devices and a topical treatment called Neoptide. The rats were divided into five groups, with group I and II receiving Laser I (HairMax Professional 12) for 1 minute 30 seconds and 3 minutes respectively, group III receiving Laser II (Laser D68-1 Marp) for 1 minute 40 seconds, group IV receiving topical Neoptide 0.3ml daily, and group V receiving both Laser I for 3 minutes and Neoptide. The hair regrowth was assessed through clinical appearance, hair weight, and histopathological examination of skin thickness, follicle count, and anagen induction percentage. The results showed that Laser I had a positive, time-dependent effect on hair regrowth, with longer exposure yielding better results. Laser II, however, induced hair loss. The combined treatment of Laser I and Neoptide resulted in better hair regrowth than either treatment alone. Thus, the combination of LLLT with Neoptide was more effective for hair regrowth in this rat model of alopecia than either treatment by itself.

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