Hair Loss Induced by Lopinavir-Ritonavir

July 2007 in “ Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy ”

Joaquı́n Borrás-Blasco, A Belda, D Rosique-Robles, Elvira Mora, Javier Abad, Isabel Amorós-Quiles

lopinavir-ritonavir HAART alopecia efavirenz HIV treatment hair loss

TLDR The medication lopinavir-ritonavir may cause severe hair loss.

In 2007, a 38-year-old Caucasian woman with HIV experienced severe hair loss after her HAART regimen was changed to include lopinavir-ritonavir. The hair loss began three months after the medication change and improved significantly within 4 weeks, completely reversing in 8 weeks after lopinavir-ritonavir was discontinued and efavirenz was started. This case indicated that alopecia could be a probable adverse reaction to lopinavir-ritonavir, and clinicians should consider medication changes if severe hair loss occurs to maintain patient adherence to HIV treatment due to the psychological and social impacts of hair loss.

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