Hair Follicle Culture: A Historical Perspective

July 2013 in “ Hair transplant forum international ”

Michael P. Philpott

hair follicle culture in vitro culture techniques hair follicle biology hair growth genetic influences hormonal influences environmental influences therapeutic approaches hair loss hair-related disorders

Studysummary This abstract lacks results; it aims to understand hair follicle regulation mechanisms but does not report specific findings or data. Our plain-language summary of this paper — not a Tressless recommendation.

The document provided a historical overview of hair follicle culture, focusing on the advancements in understanding the mechanisms regulating hair follicle growth and development. It highlighted key milestones in the field, including the development of in vitro culture techniques that allowed for the detailed study of hair follicle biology. These techniques enabled researchers to investigate the effects of various factors on hair growth, shedding light on the complex interactions between genetic, hormonal, and environmental influences. The review underscored the importance of these studies in paving the way for potential therapeutic approaches to treat hair loss and other hair-related disorders.

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research Cyclical Changes in Rat Vibrissa Follicles Maintained In Vitro

34 citations , December 2000 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study observed that rat vibrissa hair follicles cultured in vitro showed morphological changes suggesting cyclical activity but remained blocked in the pro-anagen stage.

research Specific Inhibition of Hair Follicle Formation by Epidermal Growth Factor in an Organ Culture of Developing Mouse Skin

50 citations , September 1997 in “Developmental Biology”

A Model System for Long-Term Serum-Free Suspension Organ Culture of Human Fetal Tissues: Experiments on Digits and Skin from Multiple Body Regions

research A Model System for Long-Term Serum-Free Suspension Organ Culture of Human Fetal Tissues: Experiments on Digits and Skin from Multiple Body Regions

17 citations , January 1997 in “Cell and Tissue Research”

This study found that a serum-free DMEM-F12 medium with 45% oxygen best supports in vitro development and differentiation of human fetal skin, closely mimicking the in vivo state.

research Prolonged Maintenance of Human Hair Follicles In Vitro in a Serum-Free Medium

36 citations , October 1993 in “British Journal of Dermatology”

In this study, isolated human hair follicles maintained prolonged growth and consistent DNA and keratin synthesis patterns in a fully defined medium for at least 9 days while preserving in vivo-like morphology.

research Organ Culture of Human Hair Follicles in Serum-Free Medium

27 citations , January 1993 in “Archives of Dermatological Research”

In this study, minoxidil sulphate was observed to significantly increase DNA synthesis in cultured human hair follicles in a concentration-dependent manner.

research Human Hair Growth In Vitro

385 citations , November 1990 in “Journal of Cell Science”

This study successfully grew and maintained human hair follicles in vitro, noting that TGF-β1 negatively affects growth, while EGF replicates hair-removal effects seen in animals.

research Minoxidil Stimulates Mouse Vibrissae Follicles in Organ Culture

121 citations , March 1989 in “Journal of Investigative Dermatology”

Minoxidil can help grow hair in mice by making cells grow and improving hair quality. More research needed.

research Cultivation of Murine Hair Follicles as Organoids in a Collagen Matrix

87 citations , October 1987 in “Journal of Investigative Dermatology”

research Basal Lamina Changes During Tissue Interactions in Hair Follicles: An In Vitro Study of Normal Dermal Papillae and Vitamin A-Induced Glandular Morphogenesis

34 citations , January 1983 in “Journal of Investigative Dermatology”

research In Vitro Growth of Postembryonic Hair

38 citations , August 1973 in “Journal of Investigative Dermatology”