Acute Exposure to Hair Bleach Causes Airway Hyperresponsiveness in a Rabbit Model

The study investigated the effects of hair bleach aerosols, containing ammonium persulphate, potassium persulphate, and hydrogen peroxide, on airway responsiveness in rabbits. After 4 hours of exposure, the aerosols did not affect baseline airway resistance or other respiratory parameters. However, hair bleach aerosols with persulphate concentrations of ≥10.9 mg/m³ and H2O2 concentrations of ≥1.36 mg/m³ induced airway hyperresponsiveness to acetylcholine. In contrast, aerosolized H2O2 alone at concentrations ≥37 mg/m³ did not affect airway responsiveness. The findings indicated that hair bleaching products with persulphates in H2O2 could cause airway hyperresponsiveness in rabbits.