Gomez-Lopez-Hernandez Syndrome: Another Consideration in Focal Congenital Alopecia
July 2007
in “
British Journal of Dermatology
”
Gomez-Lopez-Hernandez syndrome focal congenital alopecia trigeminal anaesthesia craniosynostosis bitemporal alopecia hypotonia plagiocephaly strabismus febrile convulsions GLHS focal scalp alopecia trigeminal nerve anaesthesia skull malformation temporal hair loss muscle weakness asymmetrical head shape crossed eyes fever-induced seizures
TLDR Gomez–Lopez–Hernandez syndrome can cause focal hair loss and developmental delays but some children can still function well and excel in school and sports.
Gomez–Lopez–Hernandez syndrome (GLHS) is a rare neurocutaneous disorder characterized by cerebellar malformation, trigeminal anaesthesia, focal scalp alopecia, and craniosynostosis. A reported case involved a boy with bitemporal alopecia from birth, hypotonia, and plagiocephaly. Despite normal chromosomes, metabolic screening, and head ultrasound, he experienced delayed motor milestones, strabismus, and recurrent febrile convulsions. By age 4.5, he functioned normally with poor balance, attended mainstream school, and excelled academically and in sports. At 9, he had a mild head injury with temporary double vision and headaches.
