GMP-Compliant Culture of Human Hair Follicle Cells for Encapsulation and Transplantation
January 2012
in “Cell Transplantation”
TLDR Researchers successfully grew human hair follicle cells that could potentially lead to new hair loss treatments.
In the 2012 study, researchers successfully cultured human hair follicle cells, specifically bulge and dermal papilla cells, under Good Manufacturing Practice (GMP) conditions, aiming to create a new treatment for alopecia through regenerative cell therapy. The cells showed high proliferation rates and the ability to produce extracellular matrix. Immunofluorescence confirmed the presence of stem cell markers, indicating the preservation of stem cell characteristics after in vitro expansion. The cells were able to organize into structures resembling hair follicles when placed in the dermis, suggesting their potential for tissue regeneration and hair follicle bioengineering. This study, supported by Pavia and Milan Universities among others, is the first to establish a method for producing bioengineered hair follicles in a GMP cell factory, which could lead to innovative treatments for alopecia. However, the study did not specify the number of people involved, and further research is needed to understand the regenerative capacity of different skin compartments for new hair follicle formation.
View this study on journals.sagepub.com →
Cited in this study
research Hair morphogenesisin vitro: formation of hair structures suitable for implantation
Scientists created early-stage hairs from mouse cells that grew into normal, pigmented hair when implanted into other mice.
research The surgical treatment of cicatricial alopecia
The document concludes that surgery is a preferred treatment for cicatricial alopecia, with the method chosen based on individual factors and may require multiple sessions and careful postoperative care.
research Microencapsulated human hair dermal papilla cells: a substitute for dermal papilla?
Encapsulated human hair cells can substitute for natural hair cells to grow hair.
research Skin and hair: models for exploring organ regeneration
Skin and hair can help us understand organ regeneration, especially how certain stem cells might be used to form new organs.
research Hair follicle stem cells: Walking the maze
Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.
research Characterization and isolation of stem cell-enriched human hair follicle bulge cells
Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.
research Follicular cell implantation: an update on “hair follicle cloning”
The document concludes that while "hair follicle cloning" shows promise for unlimited donor hair, it faces challenges with consistency and safety in humans.
research The Biology of Hair Follicles
Hair follicle biology advancements may lead to better hair growth disorder treatments.
Related
research Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes
Substances from human hair cells can affect hair loss-related genes, potentially leading to new treatments for baldness.
research A model system to analyse the ability of human keratinocytes to form hair follicles
Scientists developed a system to study human hair growth using skin cells, which could help understand hair development and improve skin substitutes for medical use.
research Review of hair follicle dermal cells
Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.
research STUDY ON HAIR FOLLICLE FORMATION INDUED BY DERAMAL PAPILLA CELL
research Trans‐species hair growth induction by human hair follicle dermal papillae
Human hair follicle cells can grow hair when put into mouse skin if they stay in contact with mouse cells.
research Role of hair papilla cells on induction and regeneration processes of hair follicles
Hair papilla cells can create and regenerate hair bulbs under the right conditions.