The Genetics of Alopecia Areata

    December 2001 in “ Dermatologic Therapy ”
    Vincent M. Aita, Angela M. Christiano
    Image of study
    TLDR Alopecia areata has a complex genetic basis that was not fully understood as of 2001.
    The document from 2001 reviews the understanding of the genetics of alopecia areata (AA), a condition with a significant genetic component, as evidenced by a higher prevalence of AA in first-degree relatives and a 55% concordance rate in monozygotic twins. Epidemiological studies and associations with HLA alleles suggest a complex genetic basis, but specific genes had not been identified. The review discusses the challenges of genetic research in complex diseases and the potential of new methods, such as microarray analyses and the use of SNPs, to uncover the genetic factors of AA. The Human Genome Project is highlighted as a valuable resource for this research, although the genetic basis for AA remained unknown at the time of writing.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 1000+ results

      community Pattern hair loss could be due to gut bacteria

       51 upvotes 6 years ago
      Feeding bacteria-free mice with Lactobacillus murinus worsened hair loss, but a regular diet with biotin stopped it. The conversation suggests gut bacteria and diet may influence hair loss, with some skepticism and discussion about other factors like DHT and genetics.

      community Is there any chance of improvement?

      in Minoxidil  8 upvotes 3 years ago
      A 19-year-old experiencing severe hair loss since 16 is using a treatment regimen of 5% minoxidil, 0.1% finasteride topical solution, 3% procapil hair serum, and 0.5 mg dutasteride daily. They are concerned about the effectiveness and potential shedding phase, with advice suggesting noticeable changes in 6 to 8 months.

    Similar Research

    5 / 1000+ results