Development of the Composition of the Gel Base for Treating Telogen Effluvium

    December 2016 in “ Vìsnik farmacìï ”
    М. І. Fedorovska, Н. П. Половко
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    TLDR The best gel to treat a type of hair loss has 1% sodium alginate, 1% carbopol, 5% glycerin, 0.2% potassium sorbate, and water.
    Seven years ago, a study was conducted to develop an optimal composition for a gel base to treat telogen effluvium, a type of hair loss. The researchers found that a preservative, potassium sorbate, at a concentration of 0.2% provided a pH of 5 to the base, which is within the skin's physiological acid-alkaline range. This concentration also resulted in optimal technological and consumer properties of the gel base, including structural viscosity, thixotropy, and mechanical stability. Biopharmaceutical and rheological studies confirmed that a base with 5% glycerin had the best ability to retain moisture, had an insignificant osmotic effect, and had proper viscosity compared to other hydrophilic non-aqueous solvents. The optimal gel base composition was determined to be: sodium alginate – 1.0 g; carbopol (Ultrez 10) – 1.0 g; glycerin – 5.0; potassium sorbate – 0.2; purified water – up to 100.0 g.
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