Clinicopathological Features of Frontal Fibrosing Alopecia in 26 Females: A Retrospective Study

July 2024 in “ Iranian journal of pathology ”

Maryam Khalili, Nafise Esmaeilpour, Simin Shamsi Meymandi, Reza Amiri, Fatemeh Gheisoori, Mahin Aflatoonian

frontal fibrosing alopecia eyebrow hair loss vellus hairs perifollicular erythema perifollicular fibrosis sebaceous gland destruction

TLDR Frontal fibrosing alopecia mainly affects women over 50, causing hair loss and specific skin changes.

This retrospective study of 26 female patients with frontal fibrosing alopecia (FFA) found that it predominantly affects women over 50, with a mean age of 50.73 years. All patients had frontal region involvement, and 38.5% experienced eyebrow hair loss. Clinically, 96.2% lacked vellus hairs in the frontotemporal regions, and 92.3% had perifollicular erythema. Pathological findings included vellus hair involvement (84.6%), replacement of follicular epithelium with a fibrous sheath (80.8%), and sebaceous gland destruction (69.2%). Perifollicular fibrosis was observed in 50% of biopsies. The study emphasizes the importance of these features for accurate diagnosis and differentiation from other hair loss types.

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