FORMATION OF A REGULAR NEO-EPIDERMIS BY CULTURED HUMAN OUTER ROOT SHEATH CELLS GRAFTED ON NUDE MICE

The study demonstrated that human outer root sheath cells from hair follicles could be cultured and grafted onto nude mice to form a stratified epithelium similar to normal epidermis. These cells expressed typical epidermal differentiation markers and showed potential as a viable source for skin replacement, offering advantages over interfollicular keratinocytes. The findings suggested that outer root sheath cells could effectively contribute to epidermal regeneration, making them a promising option for skin healing and replacement therapies.