Formulation and Design of Finasteride Coated Microneedles

    January 2021 in “ Zenodo (CERN European Organization for Nuclear Research) ”
    Mahesh Balakrishnan, Perumallu sudarsanam, Baby shalini M, K. Mounika, M. Anusha
    TLDR Finasteride-coated microneedles effectively deliver the drug with minimal scalp damage and high stability.
    The study focused on the formulation and design of finasteride-coated microneedles for treating alopecia. It aimed to enhance drug permeation while reducing scalp cell damage. The microneedles were confirmed to be coated, with a drug content of 98.80-1.60%. The drug release from the coated microneedles was 96.82%, compared to 93.93% from the marketed formulation. The f6 microneedle formulation followed zero-order release kinetics with a value of 0.737. Stability studies over 30 days showed minimal degradation, indicating the formulation's potential effectiveness and stability.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  734 upvotes 3 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

      community 3 months on minoxidil and microneedling alone

      in Progress Pictures  630 upvotes 3 years ago
      This conversation was about a user's progress pictures from using minoxidil and microneedling to treat hair loss. Other users suggested finasteride as an additional treatment, while cautioning that the drug could have permanent side effects.

      community Huberman tweet about finasteride

      in Finasteride/Dutasteride  278 upvotes 2 years ago
      The conversation is about the side effects of finasteride, including Post Finasteride Syndrome, with varied personal experiences and differing views on the credibility of information sources. Some participants also discuss using minoxidil as a hair loss treatment.

      community Why I really believe the tension theory is the cause of MPB

      in Research/Science  70 upvotes 4 years ago
      The conversation discusses the tension theory as a cause of male pattern baldness (MPB), suggesting that scalp tension and reduced subcutaneous fat layer contribute to hair loss. Treatments mentioned include Minoxidil, finasteride, microneedling, scalp massages, and Botox.

      community Please explain this Minoxidil phenomena

      in Minoxidil  57 upvotes 2 years ago
      The post discusses the difference in effects of Minoxidil (Min) on scalp and facial hair. The user questions why Min-induced hair growth on the scalp is temporary, while facial hair growth seems permanent, even after stopping Min. They propose theories, including different Min mechanisms on body and facial hair, the role of DHT, and the possibility of not achieving fully terminal hair. The responses include personal experiences and theories about Min's effects on hair growth.

      community Haircafe on why microneedling is bad for hair growth

      in Microneedling  157 upvotes 1 year ago
      Microneedling combined with minoxidil and finasteride shows significant hair regrowth, though opinions on its effectiveness vary. Some users report substantial benefits, while others highlight the need for more research and consistency in application.

    Related Research

    3 / 3 results