Formulation and Design of Finasteride Coated Microneedles

January 2021 in “ Zenodo (CERN European Organization for Nuclear Research) ”

Mahesh Balakrishnan, Perumallu sudarsanam, Baby shalini M, K. Mounika, M. Anusha

finasteride microneedles alopecia scalp cell damage drug permeation drug release zero-order release kinetics stability studies Propecia

TLDR Finasteride-coated microneedles effectively deliver the drug with minimal scalp damage and high stability.

The study focused on the formulation and design of finasteride-coated microneedles for treating alopecia. It aimed to enhance drug permeation while reducing scalp cell damage. The microneedles were confirmed to be coated, with a drug content of 98.80-1.60%. The drug release from the coated microneedles was 96.82%, compared to 93.93% from the marketed formulation. The f6 microneedle formulation followed zero-order release kinetics with a value of 0.737. Stability studies over 30 days showed minimal degradation, indicating the formulation's potential effectiveness and stability.

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