Female androgenic alopecia. The 3 alpha,17 beta-androstanediol glucuronide/sex hormone binding globulin ratio as a possible marker for female pattern baldness
September 1986
in “Archives of Dermatology”
TLDR Women with more 3α,17β-androstanediol glucuronide compared to sex hormone binding globulin are more likely to have female pattern baldness.
The study examined 25 women with female pattern baldness and male pattern baldness to identify hormone markers associated with these conditions. The researchers found that women with a high ratio of 3α,17β-androstanediol glucuronide to sex hormone binding globulin and low levels of serum sex hormone binding globulin were more likely to have female pattern baldness. This type of baldness may be caused by minimal androgen excess affecting genetically sensitive hair bulbs, even in the absence of other signs of androgen excess like hirsutism or acne.
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Cited in this study
research The Metabolism and Control Mechanism of Human Hair Follicles
Human hair follicles have a unique metabolism that changes between growth stages and may contribute to baldness.
research 3 alpha, 17 beta-androstanediol glucuronide in plasma. A marker of androgen action in idiopathic hirsutism.
High levels of 3 alpha-diol glucuronide in the blood are a marker of increased androgen action in women with excessive hair growth of unknown cause.
research Common Baldness in Women
The document concludes that early diagnosis is key for treating common baldness in women, but reassurance is often the best approach as hair thinning can be a normal part of aging.
research Classification of the types of androgenetic alopecia (common baldness) occurring in the female sex
Common baldness, also known as Androgenetic Alopecia, is caused by a combination of genetic factors and hormones called androgens.
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