TLDR CTIP2 may help in skin development and maintenance.
The study investigated the expression of COUP-TF-interacting protein 2 (CTIP2), also known as Bcl11b, in mouse skin during development and adulthood. CTIP2 was found to be highly expressed in the ectoderm starting at embryonic day 10.5, with expression becoming more restricted to proliferating cells in the basal layer of the epidermis and in hair follicles as development progressed. In adult skin, CTIP2 was present in some cells of the suprabasal layer and hair follicles, but not in the dermis. The findings suggested that CTIP2 might play a role in skin development and homeostasis, particularly in a subset of K15+ CD34− skin stem cells.
387 citations
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November 2003 in “Journal of Investigative Dermatology” The study investigated the keratin 15 (K15) promoter's role in targeting epithelial stem cells in the hair follicle bulge using K15/lacZ transgenic mice. It was found that K15 expression was age-dependent and correlated with keratinocyte differentiation levels, with strong expression in less differentiated cells in the neonatal epidermis and adult bulge area. The K15 promoter specifically targeted bulge cells, which are thought to be stem cells, throughout all hair cycle stages, with 92%±3% of K15/lacZ-positive cells being label-retaining, indicating a quiescent stem cell phenotype. This research provided a valuable tool for further studies on hair follicle biology, wound healing, and carcinogenesis.
561 citations
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April 2003 in “Journal of Investigative Dermatology” 85 citations
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July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”
276 citations
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January 2005 in “International review of cytology” The document reviewed the genomic organization and expression characteristics of human hair keratin genes, highlighting their role in hair follicle biology and hereditary disorders. It noted that research on human hair keratins lagged behind studies in other species. The review discussed the complex regulatory mechanisms of hair keratin expression and the differentiation of hair follicle compartments. It also addressed keratin-related pathologies, such as epidermolysis bullosa simplex and pachyonychia congenita, which affect the outer root sheath and nail beds, respectively. The study emphasized the need for further research to understand the molecular mechanisms governing hair follicle differentiation and keratin expression.
199 citations
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January 2004 in “The International Journal of Developmental Biology” Hair follicle growth and development are controlled by specific genes and molecular signals.
