Exploring the Overlooked Roles and Mechanisms of Fibroblasts in the Foreign Body Response

The document discussed the foreign body response (FBR), a common surgical complication where a fibrotic capsule forms around an implant, often leading to pain and revision surgeries. While the immune system and biomaterials have been the focus of FBR research, the role of fibroblasts has been overlooked. The review highlighted the need to explore fibroblast subpopulations and their functions during wound healing to better understand their role in FBR. It suggested that further research at the transcriptional level could provide insights into the mechanisms of fibrous encapsulation and guide the development of antifibrotic and regenerative therapies.