Evaluation of oxidative stress, 3-Nitrotyrosine, and HMGB-1 levels in patients with wet type Age-Related Macular Degeneration

    September 2021 in “ Journal of Medical Biochemistry ”
    Zor Ramazan, İsmail Sarı, Biçer Yıldırım, İnayet Güntürk, Erkut Küçük, Serpil Erşan, Gönül Şeyda Seydel
    TLDR wAMD patients have higher oxidative stress, suggesting antioxidant treatment may help.
    This study compared oxidative stress markers in 30 patients with Wet-type Age-Related Macular Degeneration (wAMD) and 27 healthy controls. It found that HMGB-1 levels were significantly higher in wAMD patients, indicating increased oxidative stress, which may be linked to tissue necrosis and inflammation. While there was no difference in 3-nitrotyrosine levels, significant differences were observed in Total Oxidative Status (TOS) and Oxidative Stress Index (OSI) between the groups. The study suggested that antioxidant treatment should be considered alongside routine therapy for wAMD patients.
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