Evaluation of biophysical skin parameters and hair changes in patients with acne vulgaris treated with isotretinoin, and the effect of biotin use on these parameters

The study investigated the impact of isotretinoin and biotin on 60 patients with acne vulgaris, divided into two groups of 30. Both groups received isotretinoin, but Group B also received biotin supplementation. After four months, Group B experienced a significant increase in anagen hair ratio and a decrease in telogen hair ratio, indicating improved hair growth parameters. Additionally, while skin hydration decreased in both groups, the decrease was significantly less in Group B, suggesting that biotin helps maintain skin hydration. The study concluded that biotin supplementation can prevent some adverse effects of isotretinoin treatment, particularly in maintaining skin hydration and improving hair growth. However, the study's small sample size and lack of post-treatment analysis suggest the need for further research.