Etoposide Sensitizes CT26 Colorectal Adenocarcinoma to Radiation Therapy in BALB/c Mice

    January 2005 in “ 世界胃肠病学杂志：英文版（电子版） ”
    Chia-Yuan, Liu, Hui-Fen, Liao, Tsang-En, Wang, Shee-Chan, Lin Lin, Shou-Chuan, Shih, Wen-Hsuing, Chang, Yuh-Cheng, Yang Yang, Ching-Chung, Yu-Jen, Chen
    TLDR Etoposide makes radiation therapy more effective against tumors without major side effects.
    The study investigated the effect of combining etoposide with radiation therapy (RT) on CT26 colorectal adenocarcinoma in BALB/c mice. Mice were divided into four groups: control, etoposide, RT, and combination therapy. Results showed that tumor growth was significantly inhibited by both RT and the combination therapy, with the combination therapy being more effective than RT alone. There were no significant changes in body weight, plasma alanine aminotransferase, or creatinine levels across the groups. Although leukocyte counts decreased significantly in the RT and combination therapy groups, this effect was transient. Importantly, no skin changes or hair loss were observed. The study concluded that etoposide effectively sensitized the tumors to RT without causing significant toxicity.
    Discuss this study in the Community →