Epidermolysis Bullosa Acquisita Occurring in a Patient with Systemic Lupus Erythematosus

A 23-year-old woman with a 12-year history of exfoliative skin, initially presenting as itchy blisters on the buttocks that spread and ruptured, was diagnosed with both Epidermolysis Bullosa Acquisita (EBA) and Systemic Lupus Erythematosus (SLE). Her condition worsened over a year, with symptoms including hair loss, weight loss, and oral ulcers. Dermatological and laboratory examinations revealed various skin abnormalities, anemia, hypoalbuminemia, and a positive Coombs test. Histopathology confirmed subepidermal blisters. The patient was treated with intravenous methylprednisolone. The study suggested a genetic link between EBA and SLE, particularly involving the HLA-DR2 haplotype, which may contribute to the aggressive nature of SLE in EBA patients.