Eosinophilia Associated with Clozapine – A Case Report

The document reports on a 22-year-old female with a treatment-resistant psychotic disorder who developed eosinophilia and a skin rash after starting treatment with clozapine. Her eosinophil levels increased from 6.6 × 10^8/L to a peak of 10.0 × 10^8/L ten days after initiating the medication. Despite these side effects, discontinuation of clozapine was not considered necessary. With careful monitoring and ruling out other potential causes, the patient's eosinophilia and rash resolved on their own within three months. This case emphasizes the need for vigilant hematologic monitoring in patients taking clozapine, beyond the well-known risk of agranulocytosis.