Enterococcus faecium secreted the NlpC/P60 family protein to enhance host immunity and indirectly increases Akkermansia muciniphila for slowing aging

The study explores the anti-aging effects of Enterococcus faecium fermentation broth in aged mice, demonstrating its potential to extend lifespan and improve age-related conditions such as alopecia and organ degeneration. The broth, which contains bioactive components like inositol and D-ribose, enhances hair growth, modulates gut microbiota by increasing Akkermansia muciniphila, and improves intestinal health. The secreted NlpC/P60 protein in the broth contributes to these effects by enhancing host immunity and reducing senescence markers. The study highlights the safety of using cell-free fermentation broth over live bacteria and calls for further research to confirm its efficacy and safety in humans, noting limitations due to a small sample size.