Efficacy of Topical Nanoemulsion (NB-002) for the Treatment of Distal Subungual Onychomycosis: A Randomized, Double-Blind, Vehicle-Controlled Trial

    February 2010 in “ Journal of The American Academy of Dermatology ”
    Image of study
    TLDR NB-002 is a promising new topical treatment for fungal nail infections, showing better results than a non-medicated option.
    In a study from March 2010, a novel topical antifungal agent, NB-002, was evaluated for its efficacy in treating distal subungual onychomycosis (DSO) in a randomized, double-blind, vehicle-controlled trial. The study included 227 subjects aged 18 to 75 with mild to moderate DSO, defined as ≤50% nail involvement at baseline. Subjects were randomized to receive different concentrations of NB-002 or a vehicle, applied to all toenails and adjacent skin for 42 weeks. The results showed that 4 to 8 weeks posttreatment, mycologic cure rates (negative dermatophyte culture and KOH microscopy) for the NB-002 treatment groups ranged from 25.0% to 31.7%, compared to 8.8% for the vehicle group. Effective treatment rates (mycologic cure plus ≤10% disease involvement or ≥5mm of new nail growth) ranged from 4.2% to 16.9% for NB-002 groups versus 5.3% for the vehicle group. The study concluded that NB-002 demonstrated clear antifungal activity and clinically significant nail clearing, suggesting it as a potential new topical treatment for DSO with an excellent safety profile.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Efficacy and Systemic DHT Suppression of Topical Finasteride vs Dutasteride

      in General  122 upvotes 1 week ago
      Topical dutasteride may have limited absorption due to its higher molecular mass compared to finasteride, potentially affecting its efficacy in suppressing DHT locally. Microneedling might enhance dutasteride absorption, possibly offering stronger local DHT suppression with fewer systemic effects.

      community How effective is topical spironolactone for androgenic alopecia?

      in Female  1 upvotes 1 week ago
      Topical spironolactone is discussed as a potential treatment for androgenic alopecia, with the user seeking feedback on its effectiveness. Minoxidil, finasteride, and other treatments like microneedling and keto shampoo are mentioned as alternatives.

      community Topical fin 0.025%, min 5% - 2,5 months progress

      in Finasteride/Dutasteride  9 upvotes 1 month ago
      The user started using topical finasteride 0.025% and minoxidil 5% twice daily, seeing initial improvement but later experiencing shedding and scalp pain. They are considering increasing the finasteride dose to 0.05% while using keto shampoo and dermarolling, and are debating the effectiveness of low versus standard doses of finasteride.

      community Topical - Dosage help (0.3% FIN per mL?)

      in Finasteride/Dutasteride  1 upvotes 1 month ago
      The user is considering starting a topical treatment for hair loss, using a spray containing 0.3% finasteride, 5% minoxidil, and 0.01% tretinoin. They are questioning the dosage and considering reducing the application to achieve 0.15% finasteride and 5% minoxidil.

    Similar Research

    5 / 1000+ results