Efficacy of 0.1% Adapalene in a Non-Inflammatory Kyoto Rhino Rat Acne Model

August 2014 in “ Journal of dermatological science ”

Takashi Yoshimasu, Takashi Kuramoto, Chikako Kaminaka, Nobuo Kanazawa, Yuki Yamamoto, Fukumi Furukawa

adapalene comedones epidermal thickness lipid production cytokine production IL-10 IL-12a Differin

TLDR Adapalene 0.1% effectively reduces acne by decreasing comedones and altering skin properties.

The study assessed the efficacy of 0.1% adapalene in a non-inflammatory acne model using Kyoto rhino (krh/krh) rats, which develop comedones with hair loss. Over 12 weeks, krh/krh rats treated with adapalene showed a significant reduction in open comedone areas, increased epidermal thickness, and decreased lipid production compared to the control group. Additionally, cytokine production, including IL-10 and IL-12a, tended to increase with adapalene treatment. The results suggested that krh/krh rats are a suitable model for non-inflammatory acne and that adapalene effectively reduces open comedones by modifying lipid metabolism and cytokine production.

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