Efficacy of 0.1% Adapalene in a Non-Inflammatory Kyoto Rhino Rat Acne Model

    Takashi Yoshimasu, Takashi Kuramoto, Chikako Kaminaka, Nobuo Kanazawa, Yuki Yamamoto, Fukumi Furukawa
    TLDR Adapalene 0.1% effectively reduces acne by decreasing comedones and altering skin properties.
    The study assessed the efficacy of 0.1% adapalene in a non-inflammatory acne model using Kyoto rhino (krh/krh) rats, which develop comedones with hair loss. Over 12 weeks, krh/krh rats treated with adapalene showed a significant reduction in open comedone areas, increased epidermal thickness, and decreased lipid production compared to the control group. Additionally, cytokine production, including IL-10 and IL-12a, tended to increase with adapalene treatment. The results suggested that krh/krh rats are a suitable model for non-inflammatory acne and that adapalene effectively reduces open comedones by modifying lipid metabolism and cytokine production.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 24 results

      community the ordinary retinol & minoxidil

      in Minoxidil  13 upvotes 2 months ago
      Using retinol with minoxidil may not be as effective as tretinoin, but retinaldehyde or adapalene could be alternatives. A micro-roller with minoxidil is suggested for better results.

      community This is all I’ll use to beat the Norwood reaper

      in Treatment  7 upvotes 3 weeks ago
      The conversation discusses a hair loss treatment regimen including 5% minoxidil, 2.5mg oral minoxidil, 1mg finasteride, tretinoin cream, derma stamping, derma rolling, scalp massagers, and a mix of vitamins and minerals. The user also considers using maca and adapalene, with advice on potential scalp irritation and the effectiveness of these treatments.

    Similar Research

    5 / 250 results