TLDR Adapalene 0.1% effectively reduces acne by decreasing comedones and altering skin properties.
The study assessed the efficacy of 0.1% adapalene in a non-inflammatory acne model using Kyoto rhino (krh/krh) rats, which develop comedones with hair loss. Over 12 weeks, krh/krh rats treated with adapalene showed a significant reduction in open comedone areas, increased epidermal thickness, and decreased lipid production compared to the control group. Additionally, cytokine production, including IL-10 and IL-12a, tended to increase with adapalene treatment. The results suggested that krh/krh rats are a suitable model for non-inflammatory acne and that adapalene effectively reduces open comedones by modifying lipid metabolism and cytokine production.
9 citations
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January 2011 in “EXPERIMENTAL ANIMALS” A new rat strain with a specific gene mutation causes hair loss and kidney issues.
March 2017 in “InTech eBooks” Acne vulgaris is a common skin condition that can cause low self-esteem and depression, and early treatment is important to prevent scarring.
65 citations
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February 2009 in “The journal of investigative dermatology/Journal of investigative dermatology” Anti-acne medications may work by reducing the activity of a protein involved in acne development.
April 2024 in “International journal of women's health” Adult female acne is a complex condition that can worsen with menopause, requiring holistic treatment and tailored skincare at different life stages.
January 2019 in “ARC journal of pharmaceutical sciences” Acne can be managed with various treatments and requires psychological support due to its emotional impact.
18 citations
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June 2019 in “Clinical research in dermatology” Acne can't be cured but can be managed with treatments like benzoyl peroxide and diet changes; it's costly and can lead to scarring and mental health issues.
